Molecular communication: crosstalk between the Snf1 and other signaling pathways
Artikel i vetenskaplig tidskrift, 2015

The yeast Saccharomyces cerevisiae employs different conserved signaling pathways to adapt to altered availability of nutrient and energy sources. Crosstalk between the pathways occurs to integrate different internal and external stimuli and adjust cellular metabolism, growth and proliferation to altered environmental conditions. The main glucose repression pathway, Snf1/Mig1, plays an essential role in adaptation to glucose limitation. However, the Snf1 protein kinase is also involved in regulation of many other cellular processes. We summarize evidence that Snf1 is part of a network of communicating pathways, and we suggest research directions that may help elucidating signal flow within this network.

METHIONINE

Snf1

systems biology

SULFOXIMINE TREATMENT

crosstalk

ENCODING

Biotechnology & Applied Microbiology

Microbiology

GLUCOSE-TRANSPORTER GENE

HAPLOID INVASIVE GROWTH

YEAST SACCHAROMYCES-CEREVISIAE

PAS KINASE

DEPENDENT PROTEIN-KINASE

signaling pathways

ACTIN CYTOSKELETON

CELLULAR INTEGRITY

ACTIVATION-LOOP PHOSPHORYLATION

Mycology

ADENYLATE-CYCLASE

Författare

Sviatlana Shashkova

Göteborgs universitet

Niek Welkenhuysen

Göteborgs universitet

Stefan Hohmann

Göteborgs universitet

FEMS Yeast Research

1567-1356 (ISSN) 1567-1364 (eISSN)

Vol. 15 4

Ämneskategorier

Mikrobiologi

DOI

10.1093/femsyr/fov026

PubMed

25994786