Characterization and modeling of acousto-optic signal strengths in highly scattering media
Journal article, 2019
Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of similar to 5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Author
Alexander Bengtsson
Lund University
David Hill
Lund University
SpectraCure AB
Meng Li
Lund University
Mengqiao Di
Competence Centre for Catalysis (KCK)
Lund University
Chalmers, Chemistry and Chemical Engineering, Applied Chemistry
Magnus Cinthio
Lund University
Tobias Erlov
Lund University
Stefan Andersson-Engels
University College Cork
Tyndall National Institute at National University of Ireland, Cork
Nina Reistad
Lund University
Andreas Walther
Lund University
Lars Rippe
Lund University
Stefan Kroll
Lund University
Biomedical Optics Express
21567085 (eISSN)
Vol. 10 11 5565-5584Subject Categories
Medical Laboratory and Measurements Technologies
Atom and Molecular Physics and Optics
DOI
10.1364/BOE.10.005565