Characterization and modeling of acousto-optic signal strengths in highly scattering media
Artikel i vetenskaplig tidskrift, 2019
Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of similar to 5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Författare
Alexander Bengtsson
Lunds universitet
David Hill
Lunds universitet
SpectraCure AB
Meng Li
Lunds universitet
Mengqiao Di
Kompetenscentrum katalys
Lunds universitet
Chalmers, Kemi och kemiteknik, Tillämpad kemi
Magnus Cinthio
Lunds universitet
Tobias Erlov
Lunds universitet
Stefan Andersson-Engels
University College Cork
Tyndall National Institute at National University of Ireland, Cork
Nina Reistad
Lunds universitet
Andreas Walther
Lunds universitet
Lars Rippe
Lunds universitet
Stefan Kroll
Lunds universitet
Biomedical Optics Express
21567085 (eISSN)
Vol. 10 11 5565-5584Ämneskategorier
Medicinsk laboratorie- och mätteknik
Atom- och molekylfysik och optik
DOI
10.1364/BOE.10.005565