Hitchhiking on vesicles: a way to harness age-related proteopathies?
Journal article, 2020

The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies Central to proteopathies and leading to most age-related neurodegenerative disorders is a failure in protein quality control (PQC). To harness the toxicity of misfolded and damaged disease proteins, such proteins are either refolded, degraded by temporal PQC, or sequestered by spatial PQC into specific, organelle-associated, compartments within the cell. Here, we discuss the impact of vesicle trafficking pathways in general, and syntaxin 5 in particular, as key players in spatial PQC directing misfolded proteins to the surface of vacuole and mitochondria, which facilitates their clearance and detoxification. Since boosting vesicle trafficking genetically can positively impact on spatial PQC and make cells less sensitive to misfolded disease proteins, we speculate that regulators of such trafficking might serve as therapeutic targets for age-related neurological disorders.

vesicle trafficking

aggregate clearance


organelle contact sites

protein quality control

syntaxin 5



neurodegenerative disorders

inclusion body formation


Doryaneh Ahmadpour

University of Gothenburg

Roja Babazadeh

University of Gothenburg

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Thomas Nyström

University of Gothenburg

FEBS Journal

1742-464X (ISSN) 17424658 (eISSN)

Vol. 287 23 5068-5079

Subject Categories

Biochemistry and Molecular Biology

Immunology in the medical area

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)





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