Hitchhiking on vesicles: a way to harness age-related proteopathies?
Artikel i vetenskaplig tidskrift, 2020

The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies Central to proteopathies and leading to most age-related neurodegenerative disorders is a failure in protein quality control (PQC). To harness the toxicity of misfolded and damaged disease proteins, such proteins are either refolded, degraded by temporal PQC, or sequestered by spatial PQC into specific, organelle-associated, compartments within the cell. Here, we discuss the impact of vesicle trafficking pathways in general, and syntaxin 5 in particular, as key players in spatial PQC directing misfolded proteins to the surface of vacuole and mitochondria, which facilitates their clearance and detoxification. Since boosting vesicle trafficking genetically can positively impact on spatial PQC and make cells less sensitive to misfolded disease proteins, we speculate that regulators of such trafficking might serve as therapeutic targets for age-related neurological disorders.

protein quality control

syntaxin 5

aggregate clearance

inclusion body formation

aging

vesicle trafficking

organelle contact sites

vacuole

mitochondria

neurodegenerative disorders

Författare

Doryaneh Ahmadpour

Göteborgs universitet

Roja Babazadeh

Chalmers, Biologi och bioteknik, Systembiologi

Göteborgs universitet

Thomas Nyström

Göteborgs universitet

FEBS Journal

1742-464X (ISSN) 1432-1033 (eISSN)

Vol. In Press

Ämneskategorier

Biokemi och molekylärbiologi

Immunologi inom det medicinska området

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

DOI

10.1111/febs.15345

PubMed

32336030

Mer information

Senast uppdaterat

2020-08-24