A Robust and Biocompatible Bismuth Ellagate MOF Synthesized Under Green Ambient Conditions
Journal article, 2020
The first bioinspired microporous metal-organic framework (MOF) synthesized using ellagic acid, a common natural antioxidant and polyphenol building unit, is presented. Bi2O(H2O)2(C14H2O8)·nH2O (SU-101) was inspired by bismuth phenolate metallodrugs, and could be synthesized entirely from nonhazardous or edible reagents under ambient aqueous conditions, enabling simple scale-up. Reagent-grade and affordable dietary supplement-grade ellagic acid was sourced from tree bark and pomegranate hulls, respectively. Biocompatibility and colloidal stability were confirmed by in vitro assays. The material exhibits remarkable chemical stability for a bioinspired MOF (pH = 2-14, hydrothermal conditions, heated organic solvents, biological media, SO2 and H2S), attributed to the strongly chelating phenolates. A total H2S uptake of 15.95 mmol g-1 was recorded, representing one of the highest H2S capacities for a MOF, where polysulfides are formed inside the pores of the material. Phenolic phytochemicals remain largely unexplored as linkers for MOF synthesis, opening new avenues to design stable, eco-friendly, scalable, and low-cost MOFs for diverse applications, including drug delivery.
Author
Erik Svensson Grape
Stockholm University
J. Gabriel Flores
Universidad Autónoma Metropolitana - Azcapotzalco
Universidad Nacional Autonoma de Mexico
Tania Hidalgo
Instituto IMDEA Energía
Eva Martínez-Ahumada
Universidad Nacional Autonoma de Mexico
Aída Gutiérrez-Alejandre
Universidad Nacional Autonoma de Mexico
Audrey Hautier
Institut National des Sciences Appliquees de Lyon
Daryl R. Williams
Imperial College London
Michael O'Keeffe
Arizona State University
Lars Öhrström
Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry
Tom Willhammar
Stockholm University
Patricia Horcajada
Instituto IMDEA Energía
Ilich A. Ibarra
Universidad Nacional Autonoma de Mexico
A.K. Inge
Stockholm University
Journal of the American Chemical Society
0002-7863 (ISSN) 1520-5126 (eISSN)
Vol. 142 39 16795-16804Subject Categories
Materials Chemistry
Other Chemistry Topics
Organic Chemistry
DOI
10.1021/jacs.0c07525
PubMed
32894014