A Robust and Biocompatible Bismuth Ellagate MOF Synthesized Under Green Ambient Conditions
Artikel i vetenskaplig tidskrift, 2020

The first bioinspired microporous metal-organic framework (MOF) synthesized using ellagic acid, a common natural antioxidant and polyphenol building unit, is presented. Bi2O(H2O)2(C14H2O8)·nH2O (SU-101) was inspired by bismuth phenolate metallodrugs, and could be synthesized entirely from nonhazardous or edible reagents under ambient aqueous conditions, enabling simple scale-up. Reagent-grade and affordable dietary supplement-grade ellagic acid was sourced from tree bark and pomegranate hulls, respectively. Biocompatibility and colloidal stability were confirmed by in vitro assays. The material exhibits remarkable chemical stability for a bioinspired MOF (pH = 2-14, hydrothermal conditions, heated organic solvents, biological media, SO2 and H2S), attributed to the strongly chelating phenolates. A total H2S uptake of 15.95 mmol g-1 was recorded, representing one of the highest H2S capacities for a MOF, where polysulfides are formed inside the pores of the material. Phenolic phytochemicals remain largely unexplored as linkers for MOF synthesis, opening new avenues to design stable, eco-friendly, scalable, and low-cost MOFs for diverse applications, including drug delivery.


Erik Svensson Grape

Stockholms universitet

J. Gabriel Flores

Universidad Autónoma Metropolitana - Azcapotzalco

Universidad Nacional Autonoma de Mexico

Tania Hidalgo

Instituto IMDEA Energía

Eva Martínez-Ahumada

Universidad Nacional Autonoma de Mexico

Aída Gutiérrez-Alejandre

Universidad Nacional Autonoma de Mexico

Audrey Hautier

Institut National des Sciences Appliquees de Lyon

Daryl R. Williams

Imperial College London

Michael O'Keeffe

Arizona State University

Lars Öhrström

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Tom Willhammar

Stockholms universitet

Patricia Horcajada

Instituto IMDEA Energía

Ilich A. Ibarra

Universidad Nacional Autonoma de Mexico

A.K. Inge

Stockholms universitet

Journal of the American Chemical Society

0002-7863 (ISSN) 1520-5126 (eISSN)

Vol. 142 39 16795-16804



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