Maternal dietary selenium intake during pregnancy is associated with higher birth weight and lower risk of small for gestational age births in the norwegian mother, father and child cohort study
Journal article, 2021
Selenium is an essential trace element involved in the body’s redox reactions. Low selenium intake during pregnancy has been associated with low birth weight and an increased risk of children being born small for gestational age (SGA). Based on data from the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN), we studied the association of maternal selenium intake from diet and supplements during the first half of pregnancy (n = 71,728 women) and selenium status in mid-pregnancy (n = 2628 women) with birth weight and SGA status, according to population-based, ultrasound-based and customized growth standards. An increase of one standard deviation of maternal dietary selenium intake was associated with increased birth weight z-scores (ß = 0.027, 95% CI: 0.007, 0.041) and lower SGA risk (OR = 0.91, 95% CI 0.86, 0.97) after adjusting for confounders. Maternal organic and inorganic selenium intake from supplements as well as whole blood selenium concentration were not associated with birth weight or SGA. Our results suggest that a maternal diet rich in selenium during pregnancy may be beneficial for foetal growth. However, the effect estimates were small and further studies are needed to elucidate the potential impact of selenium on foetal growth.
Birth weight
Medical Birth Registry of Norway
MoBa
Selenium
Intrauterine growth
MBRN
The Norwegian Mother, Father and Child Cohort study
Author
Pol Sole-Navais
University of Gothenburg
Anne-Lise Brantsaeter
Norwegian Institute of Public Health
Ida Henriette Caspersen
Norwegian Institute of Public Health
Thomas Lundh
Lund University
L. J. Muglia
Burroughs Wellcome Fund
University of Cincinnati
Cincinnati Children's Hospital Medical Center
Helle M Meltzer
Norwegian Institute of Public Health
G. Zhang
University of Cincinnati
Cincinnati Children's Hospital Medical Center
Bo Jacobsson
Norwegian Institute of Public Health
University of Gothenburg
Sahlgrenska University Hospital
Verena Sengpiel
Sahlgrenska University Hospital
University of Gothenburg
Malin Barman
Chalmers, Biology and Biological Engineering, Food and Nutrition Science
Karolinska Institutet
Nutrients
2072-6643 (ISSN) 20726643 (eISSN)
Vol. 13 1 1-16 23Maternal selenium intake and status during pregnancy in relation to pregnancy, neonatal and child outcomes
The Royal Society of Arts and Sciences in Gothenburg (2017-054), 2018-01-01 -- 2018-12-31.
Stiftelsen Wilhelm och Martina Lundgrens Vetenskapsfond (2017-1788), 2018-01-01 -- 2018-12-31.
Subject Categories (SSIF 2011)
Pediatrics
Obstetrics, Gynecology and Reproductive Medicine
Nutrition and Dietetics
DOI
10.3390/nu13010023
PubMed
33374667