Maternal dietary selenium intake during pregnancy is associated with higher birth weight and lower risk of small for gestational age births in the norwegian mother, father and child cohort study
Artikel i vetenskaplig tidskrift, 2021

Selenium is an essential trace element involved in the body’s redox reactions. Low selenium intake during pregnancy has been associated with low birth weight and an increased risk of children being born small for gestational age (SGA). Based on data from the Norwegian Mother, Father and Child Cohort Study (MoBa) and the Medical Birth Registry of Norway (MBRN), we studied the association of maternal selenium intake from diet and supplements during the first half of pregnancy (n = 71,728 women) and selenium status in mid-pregnancy (n = 2628 women) with birth weight and SGA status, according to population-based, ultrasound-based and customized growth standards. An increase of one standard deviation of maternal dietary selenium intake was associated with increased birth weight z-scores (ß = 0.027, 95% CI: 0.007, 0.041) and lower SGA risk (OR = 0.91, 95% CI 0.86, 0.97) after adjusting for confounders. Maternal organic and inorganic selenium intake from supplements as well as whole blood selenium concentration were not associated with birth weight or SGA. Our results suggest that a maternal diet rich in selenium during pregnancy may be beneficial for foetal growth. However, the effect estimates were small and further studies are needed to elucidate the potential impact of selenium on foetal growth.

MoBa

Birth weight

The Norwegian Mother, Father and Child Cohort study

Intrauterine growth

Selenium

MBRN

Medical Birth Registry of Norway

Författare

Pol Sole-Navais

Göteborgs universitet

Anne-Lise Brantsaeter

Norwegian Institute of Public Health

Ida Henriette Caspersen

Norwegian Institute of Public Health

Thomas Lundh

Lunds universitet

L. J. Muglia

University of Cincinnati

Burroughs Wellcome Fund

Cincinnati Children's Hospital Medical Center

Helle M Meltzer

Norwegian Institute of Public Health

G. Zhang

University of Cincinnati

Cincinnati Children's Hospital Medical Center

Bo Jacobsson

Göteborgs universitet

Norwegian Institute of Public Health

Sahlgrenska universitetssjukhuset

Verena Sengpiel

Sahlgrenska universitetssjukhuset

Göteborgs universitet

Malin Barman

Karolinska Institutet

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Nutrients

2072-6643 (ISSN)

Vol. 13 1 1-16 23

Ämneskategorier

Pediatrik

Reproduktionsmedicin och gynekologi

Näringslära

DOI

10.3390/nu13010023

PubMed

33374667

Mer information

Senast uppdaterat

2021-01-21