Maternal dietary selenium intake during pregnancy and neonatal outcomes in the norwegian mother, father, and child cohort study
Journal article, 2021

Properly working antioxidant defence systems are important for fetal development. One of the nutrients with antioxidant activity is selenium. Increased maternal selenium intake has been associated with reduced risk for being small for gestational age and preterm delivery. Based on the Norwegian Mother, Father, and Child Cohort Study and the Medical Birth Registry of Norway, we in-vestigated the association of maternal selenium intake from food and dietary supplements during the first half of pregnancy (n = 71,728 women) and selenium status in mid-pregnancy (n = 2628 women) with neonatal health, measured as two composite variables (neonatal morbidity/mortality and neonatal intervention). Low maternal dietary selenium intake (<30 µg/day) was associated with increased risk for neonatal morbidity/mortality (adjusted odds ratio (adjOR) 1.36, 95% confidence interval (95% CI) 1.08–1.69) and neonatal intervention (adjOR 1.16, 95% CI 1.01–1.34). Using continuous variables, there were no associations between maternal selenium intake (from diet or supplements) or whole-blood selenium concentration and neonatal outcome in the adjusted models. Our findings suggest that sufficient maternal dietary selenium intake is associated with neonatal outcome. Adher-ing to the dietary recommendations may help ensure an adequate supply of selenium for a healthy pregnancy and optimal fetal development.

Small for gestational age

Medical Birth Registry of Norway

Norwegian Mother, Father, and Child Cohort Study

Pregnancy

Neonatal outcome

MoBa

MBRN

Selenium

Author

Dominika Modzelewska

University of Gothenburg

Pol Sole-Navais

University of Gothenburg

Anne-Lise Brantsaeter

Norwegian Institute of Public Health

Christopher Flatley

University of Gothenburg

Anders Elfvin

Sahlgrenska University Hospital

Helle M Meltzer

Norwegian Institute of Public Health

Verena Sengpiel

University of Gothenburg

Sahlgrenska University Hospital

Malin Barman

Karolinska Institutet

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Bo Jacobsson

University of Gothenburg

Norwegian Institute of Public Health

Sahlgrenska University Hospital

Nutrients

2072-6643 (ISSN) 20726643 (eISSN)

Vol. 13 4 1239

Maternal selenium intake and status during pregnancy in relation to pregnancy, neonatal and child outcomes

Stiftelsen Wilhelm och Martina Lundgrens Vetenskapsfond (2017-1788), 2018-01-01 -- 2018-12-31.

The Royal Society of Arts and Sciences in Gothenburg (2017-054), 2018-01-01 -- 2018-12-31.

Subject Categories

Pediatrics

Public Health, Global Health, Social Medicine and Epidemiology

Obstetrics, Gynecology and Reproductive Medicine

Nutrition and Dietetics

DOI

10.3390/nu13041239

PubMed

33918747

More information

Latest update

10/9/2023