Maternal dietary selenium intake during pregnancy and neonatal outcomes in the norwegian mother, father, and child cohort study
Artikel i vetenskaplig tidskrift, 2021

Properly working antioxidant defence systems are important for fetal development. One of the nutrients with antioxidant activity is selenium. Increased maternal selenium intake has been associated with reduced risk for being small for gestational age and preterm delivery. Based on the Norwegian Mother, Father, and Child Cohort Study and the Medical Birth Registry of Norway, we in-vestigated the association of maternal selenium intake from food and dietary supplements during the first half of pregnancy (n = 71,728 women) and selenium status in mid-pregnancy (n = 2628 women) with neonatal health, measured as two composite variables (neonatal morbidity/mortality and neonatal intervention). Low maternal dietary selenium intake (<30 µg/day) was associated with increased risk for neonatal morbidity/mortality (adjusted odds ratio (adjOR) 1.36, 95% confidence interval (95% CI) 1.08–1.69) and neonatal intervention (adjOR 1.16, 95% CI 1.01–1.34). Using continuous variables, there were no associations between maternal selenium intake (from diet or supplements) or whole-blood selenium concentration and neonatal outcome in the adjusted models. Our findings suggest that sufficient maternal dietary selenium intake is associated with neonatal outcome. Adher-ing to the dietary recommendations may help ensure an adequate supply of selenium for a healthy pregnancy and optimal fetal development.

Medical Birth Registry of Norway



Neonatal outcome

Small for gestational age

Norwegian Mother, Father, and Child Cohort Study




Dominika Modzelewska

Göteborgs universitet

Pol Sole-Navais

Göteborgs universitet

Anne-Lise Brantsaeter

Norwegian Institute of Public Health

Christopher Flatley

Göteborgs universitet

Anders Elfvin

Sahlgrenska universitetssjukhuset

Helle M Meltzer

Norwegian Institute of Public Health

Verena Sengpiel

Sahlgrenska universitetssjukhuset

Göteborgs universitet

Malin Barman

Karolinska Institutet

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Bo Jacobsson

Norwegian Institute of Public Health

Göteborgs universitet

Sahlgrenska universitetssjukhuset


2072-6643 (ISSN) 20726643 (eISSN)

Vol. 13 4 1239


Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

Reproduktionsmedicin och gynekologi






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