A Perspective on Synthetic Biology in Drug Discovery and Development - Current Impact and Future Opportunities
Review article, 2021

The global impact of synthetic biology has been accelerating, because of the plummeting cost of DNA synthesis, advances in genetic engineering, growing understanding of genome organization, and explosion in data science. However, much of the discipline’s application in the pharmaceutical industry remains enigmatic. In this review, we highlight recent examples of the impact of synthetic biology on target validation, assay development, hit finding, lead optimization, and chemical synthesis, through to the development of cellular therapeutics. We also highlight the availability of tools and technologies driving the discipline. Synthetic biology is certainly impacting all stages of drug discovery and development, and the recognition of the discipline’s contribution can further enhance the opportunities for the drug discovery and development value chain.

CRISPR-Cas9

late-stage functionalization

chassis organism

biofoundry

drug discovery

synthetic biology

Author

Florian David

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Andrew M. Davis

AstraZeneca AB

Michael Gossing

AstraZeneca AB

Martin A. Hayes

AstraZeneca AB

Elvira Romero

AstraZeneca AB

Louis H. Scott

AstraZeneca AB

Mark J. Wigglesworth

AstraZeneca AB

SLAS Discovery

24725552 (ISSN) 24725560 (eISSN)

Vol. 26 5 581-603

Subject Categories

Other Mechanical Engineering

Software Engineering

Bioinformatics and Systems Biology

DOI

10.1177/24725552211000669

PubMed

33834873

More information

Latest update

8/18/2021