A Novel Graphene Quantum Dot-Based mRNA Delivery Platform
Journal article, 2021

During the last decades, there has been growing interest in using therapeutic messager RNA (mRNA) together with drug delivery systems. Naked, unformulated mRNA is, however, unable to cross the cell membrane and is susceptible to degradation. Here we use graphene quantum dots (GQDs) functionalized with polyethyleneimine (PEI) as a novel mRNA delivery system. Our results show that these modified GQDs can be used to deliver intact and functional mRNA to Huh-7 hepatocarcinoma cells at low doses and, that the GQDs are not toxic, although cellular toxicity is a problem for these first-generation modified particles. Functionalized GQDs represent a potentially interesting delivery system that is easy to manufacture, stable and effective.

functionalization

mRNA

hepatocarcinoma

graphene quantum dots

drug delivery

Author

Ya Liu

Fudan University

Chalmers, Microtechnology and Nanoscience (MC2), Electronics Material and Systems Laboratory

Changhong Zhao

Xinxiang Medical University

Chalmers, Microtechnology and Nanoscience (MC2), Electronics Material and Systems Laboratory

Alan Sabirsh

AstraZeneca R&D

Lilei Ye

SHT Smart High-Tech

Xiaoqiu Wu

AstraZeneca R&D

Hongbin Lu

Fudan University

Johan Liu

Chalmers, Microtechnology and Nanoscience (MC2), Electronics Material and Systems Laboratory

Shanghai University

ChemistryOpen

2191-1363 (eISSN)

Vol. In Press

Subject Categories

Cell Biology

Cell and Molecular Biology

Pharmacology and Toxicology

Areas of Advance

Production

DOI

10.1002/open.202000200

PubMed

33829677

More information

Latest update

5/11/2021