Contrasting evolutionary genome dynamics between domesticated and wild yeasts
Journal article, 2017
Structural rearrangements have long been recognized as an important source of genetic variation, with implications in phenotypic diversity and disease, yet their detailed evolutionary dynamics remain elusive. Here we use long-read sequencing to generate end-to-end genome assemblies for 12 strains representing major subpopulations of the partially domesticated yeast Saccharomyces cerevisiae and its wild relative Saccharomyces paradoxus. These population-level high-quality genomes with comprehensive annotation enable precise definition of chromosomal boundaries between cores and subtelomeres and a high-resolution view of evolutionary genome dynamics. In chromosomal cores, S. paradoxus shows faster accumulation of balanced rearrangements (inversions, reciprocal translocations and transpositions), whereas S. cerevisiae accumulates unbalanced rearrangements (novel insertions, deletions and duplications) more rapidly. In subtelomeres, both species show extensive interchromosomal reshuffling, with a higher tempo in S. cerevisiae. Such striking contrasts between wild and domesticated yeasts are likely to reflect the influence of human activities on structural genome evolution.
Author
Jia Xing Yue
University of Côte d'Azur
Jing Li
University of Côte d'Azur
Louise Aigrain
Wellcome Trust Sanger Institute
Johan Hallin
University of Côte d'Azur
Karl Persson
University of Gothenburg
Karen Oliver
Wellcome Trust Sanger Institute
Anders Bergström
Wellcome Trust Sanger Institute
Paul Coupland
Wellcome Trust Sanger Institute
University of Cambridge
Jonas Warringer
University of Gothenburg
Marco Cosentino Lagomarsino
Sorbonne University
Gilles Fischer
Sorbonne University
Richard Durbin
Wellcome Trust Sanger Institute
Gianni Liti
University of Côte d'Azur
Nature Genetics
1061-4036 (ISSN) 15461718 (eISSN)
Vol. 49 6 913-924Subject Categories
Genetics
DOI
10.1038/ng.3847