Contrasting evolutionary genome dynamics between domesticated and wild yeasts
Artikel i vetenskaplig tidskrift, 2017

Structural rearrangements have long been recognized as an important source of genetic variation, with implications in phenotypic diversity and disease, yet their detailed evolutionary dynamics remain elusive. Here we use long-read sequencing to generate end-to-end genome assemblies for 12 strains representing major subpopulations of the partially domesticated yeast Saccharomyces cerevisiae and its wild relative Saccharomyces paradoxus. These population-level high-quality genomes with comprehensive annotation enable precise definition of chromosomal boundaries between cores and subtelomeres and a high-resolution view of evolutionary genome dynamics. In chromosomal cores, S. paradoxus shows faster accumulation of balanced rearrangements (inversions, reciprocal translocations and transpositions), whereas S. cerevisiae accumulates unbalanced rearrangements (novel insertions, deletions and duplications) more rapidly. In subtelomeres, both species show extensive interchromosomal reshuffling, with a higher tempo in S. cerevisiae. Such striking contrasts between wild and domesticated yeasts are likely to reflect the influence of human activities on structural genome evolution.

Författare

Jia Xing Yue

Université Côte d'Azur

Jing Li

Université Côte d'Azur

Louise Aigrain

Wellcome Trust Sanger Institute

Johan Hallin

Université Côte d'Azur

Karl Persson

Göteborgs universitet

Karen Oliver

Wellcome Trust Sanger Institute

Anders Bergström

Wellcome Trust Sanger Institute

Paul Coupland

Wellcome Trust Sanger Institute

University of Cambridge

Jonas Warringer

Göteborgs universitet

Marco Cosentino Lagomarsino

Sorbonne Université

Gilles Fischer

Sorbonne Université

Richard Durbin

Wellcome Trust Sanger Institute

Gianni Liti

Université Côte d'Azur

Nature Genetics

1061-4036 (ISSN) 15461718 (eISSN)

Vol. 49 6 913-924

Ämneskategorier

Genetik

DOI

10.1038/ng.3847

Mer information

Senast uppdaterat

2022-08-10