Domestication reprogrammed the budding yeast life cycle
Journal article, 2022
Domestication of plants and animals is the foundation for feeding the world human population but can profoundly alter the biology of the domesticated species. Here we investigated the effect of domestication on one of our prime model organisms, the yeast Saccharomyces cerevisiae, at a species-wide level. We tracked the capacity for sexual and asexual reproduction and the chronological life span across a global collection of 1,011 genome-sequenced yeast isolates and found a remarkable dichotomy between domesticated and wild strains. Domestication had systematically enhanced fermentative and reduced respiratory asexual growth, altered the tolerance to many stresses and abolished or impaired the sexual life cycle. The chronological life span remained largely unaffected by domestication and was instead dictated by clade-specific evolution. We traced the genetic origins of the yeast domestication syndrome using genome-wide association analysis and genetic engineering and disclosed causative effects of aneuploidy, gene presence/absence variations, copy number variations and single-nucleotide polymorphisms. Overall, we propose domestication to be the most dramatic event in budding yeast evolution, raising questions about how much domestication has distorted our understanding of the natural biology of this key model species.
Author
Matteo De Chiara
University of Côte d'Azur
Benjamin P. Barré
University of Côte d'Azur
Karl Persson
Chalmers, Biology and Biological Engineering, Industrial Biotechnology
Agurtzane Irizar
University of Côte d'Azur
Chiara Vischioni
University of Côte d'Azur
Sakshi Khaiwal
University of Côte d'Azur
Simon Stenberg
University of Gothenburg
Amadi Onyetuga Chioma
University of Gothenburg
Gašper Žun
Jozef Stefan Institute
University of Ljubljana
Katja Doberšek
Jozef Stefan Institute
Cristian Taccioli
University of Padua
Joseph Schacherer
University of Strasbourg
Uros Petrovic
Jozef Stefan Institute
University of Ljubljana
Jonas Warringer
University of Gothenburg
Gianni Liti
University of Côte d'Azur
Nature Ecology & Evolution
2397-334X (ISSN) 2397-334X (eISSN)
Vol. 6Subject Categories
Evolutionary Biology
Ecology
Microbiology
Bioinformatics and Systems Biology
Genetics
DOI
10.1038/s41559-022-01671-9