Domestication reprogrammed the budding yeast life cycle
Artikel i vetenskaplig tidskrift, 2022
Domestication of plants and animals is the foundation for feeding the world human population but can profoundly alter the biology of the domesticated species. Here we investigated the effect of domestication on one of our prime model organisms, the yeast Saccharomyces cerevisiae, at a species-wide level. We tracked the capacity for sexual and asexual reproduction and the chronological life span across a global collection of 1,011 genome-sequenced yeast isolates and found a remarkable dichotomy between domesticated and wild strains. Domestication had systematically enhanced fermentative and reduced respiratory asexual growth, altered the tolerance to many stresses and abolished or impaired the sexual life cycle. The chronological life span remained largely unaffected by domestication and was instead dictated by clade-specific evolution. We traced the genetic origins of the yeast domestication syndrome using genome-wide association analysis and genetic engineering and disclosed causative effects of aneuploidy, gene presence/absence variations, copy number variations and single-nucleotide polymorphisms. Overall, we propose domestication to be the most dramatic event in budding yeast evolution, raising questions about how much domestication has distorted our understanding of the natural biology of this key model species.
Författare
Matteo De Chiara
Université Côte d'Azur
Benjamin P. Barré
Université Côte d'Azur
Karl Persson
Chalmers, Biologi och bioteknik, Industriell bioteknik
Agurtzane Irizar
Université Côte d'Azur
Chiara Vischioni
Université Côte d'Azur
Sakshi Khaiwal
Université Côte d'Azur
Simon Stenberg
Göteborgs universitet
Amadi Onyetuga Chioma
Göteborgs universitet
Gašper Žun
Institut Jožef Stefan
Univerza V Ljubljani
Katja Doberšek
Institut Jožef Stefan
Cristian Taccioli
Università di Padova
Joseph Schacherer
Université de Strasbourg
Uros Petrovic
Institut Jožef Stefan
Univerza V Ljubljani
Jonas Warringer
Göteborgs universitet
Gianni Liti
Université Côte d'Azur
Nature Ecology & Evolution
2397-334X (ISSN) 2397-334X (eISSN)
Vol. 6Ämneskategorier
Evolutionsbiologi
Ekologi
Mikrobiologi
Bioinformatik och systembiologi
Genetik
DOI
10.1038/s41559-022-01671-9