Regulation of functional groups enable the metal-free PDINH/GO advisable antibacterial photocatalytic therapy
Journal article, 2023
N-type organic semiconductor perylene-3,4,9,10-tetracarboxylic acid diimide (PDINH) are well-investigated photocatalyst. However, the photocatalytic potential for antibacterial therapy has been underexplored owing to the insufficient light absorption and rapid recombination of light-induced carriers. Herein, functional group-regulated is introduced by recrystallizing PDINH on the surface of GO in situ, endowing the PDINH/GO with enhanced photocatalytic properties, which harvest light energy across the full spectrum form ultraviolet to near-infrared. Simultaneously, the enhanced photogenerated carriers can activate Lewis base of GO to form an amide bond on the interface between bacteria and material, exhibiting high-efficient and steady bacteria trap. Compared with PDINH, both in vitro and in vivo all demonstrated PDINH/GO possess excellent antibacterial effect. In addition, as a non-metallic semiconductor, PDINH/GO shows capacity of enhancing epidermal cells proliferation and migration, resulting in successful infectious wound regeneration in mice and the side effects in vivo are negligible. Such the integration of wide-spectrum response, high efficiency of carrier separation, intentional bacterial capture and accelerated would healing of PDINH/GO not only enables an effective antibacterial therapy but also contributes to a successful example to activate nanomaterials by regulation of functional groups.
Non-metallic semiconductor-PDINH/GO
Energy band engineering
Functionalization
Antibacterial photocatalytic therapy
Bacteria capture
Author
Longwei Wang
Jinan University
Northwest University
Xiaowen Tang
Qingdao University
Zhongwei Yang
Jinan University
Jiawei Guo
Jinan University
Zhen You
Northwest University
Yu Cai
Northwest University
Xiaochen Niu
Northwest University
Xiaoyu Zhang
Chinese Academy of Sciences
Northwest University
Liwei Zhang
Jinan University
Jian Zhang
Chalmers, Life Sciences, Systems and Synthetic Biology
Aizhu Wang
Jinan University
Jing Liu
Chinese Academy of Sciences
Northwest University
Hong Liu
Shandong University
Jinan University
Xin Yu
Jinan University
Chemical Engineering Journal
1385-8947 (ISSN)
Vol. 451 139007Subject Categories
Materials Chemistry
Other Basic Medicine
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
DOI
10.1016/j.cej.2022.139007