Regulation of functional groups enable the metal-free PDINH/GO advisable antibacterial photocatalytic therapy
Artikel i vetenskaplig tidskrift, 2023

N-type organic semiconductor perylene-3,4,9,10-tetracarboxylic acid diimide (PDINH) are well-investigated photocatalyst. However, the photocatalytic potential for antibacterial therapy has been underexplored owing to the insufficient light absorption and rapid recombination of light-induced carriers. Herein, functional group-regulated is introduced by recrystallizing PDINH on the surface of GO in situ, endowing the PDINH/GO with enhanced photocatalytic properties, which harvest light energy across the full spectrum form ultraviolet to near-infrared. Simultaneously, the enhanced photogenerated carriers can activate Lewis base of GO to form an amide bond on the interface between bacteria and material, exhibiting high-efficient and steady bacteria trap. Compared with PDINH, both in vitro and in vivo all demonstrated PDINH/GO possess excellent antibacterial effect. In addition, as a non-metallic semiconductor, PDINH/GO shows capacity of enhancing epidermal cells proliferation and migration, resulting in successful infectious wound regeneration in mice and the side effects in vivo are negligible. Such the integration of wide-spectrum response, high efficiency of carrier separation, intentional bacterial capture and accelerated would healing of PDINH/GO not only enables an effective antibacterial therapy but also contributes to a successful example to activate nanomaterials by regulation of functional groups.

Non-metallic semiconductor-PDINH/GO

Energy band engineering

Functionalization

Antibacterial photocatalytic therapy

Bacteria capture

Författare

Longwei Wang

Jinan University

Northwest University

Xiaowen Tang

Qingdao University

Zhongwei Yang

Jinan University

Jiawei Guo

Jinan University

Zhen You

Northwest University

Yu Cai

Northwest University

Xiaochen Niu

Northwest University

Xiaoyu Zhang

Chinese Academy of Sciences

Northwest University

Liwei Zhang

Jinan University

Jian Zhang

Chalmers, Life sciences, Systembiologi

Aizhu Wang

Jinan University

Jing Liu

Chinese Academy of Sciences

Northwest University

Hong Liu

Shandong University

Jinan University

Xin Yu

Jinan University

Chemical Engineering Journal

1385-8947 (ISSN)

Vol. 451 139007

Ämneskategorier

Materialkemi

Annan medicinsk grundvetenskap

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

DOI

10.1016/j.cej.2022.139007

Mer information

Senast uppdaterat

2022-09-30