Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants
Journal article, 2023
Flexible implantable neurointerfaces show great promise in addressing one of the major challenges of implantable neurotechnology, namely the loss of signal connected to unfavorable probe tissue interaction. The authors here show how multilayer polyimide probes allow high-density intracortical recordings to be combined with a reliable long-term stable tissue interface, thereby progressing toward chronic stability of implantable neurotechnology. The probes could record 10–60 single units over 5 months with a consistent peak-to-peak voltage at dimensions that ensure robust handling and insulation longevity. Probes that remain in intimate contact with the signaling tissue over months to years are a game changer for neuroscience and, importantly, open up for broader clinical translation of systems relying on neurotechnology to interface the human brain.
bioelectronics
tissue-device interfaces
conducting polymers
flexible probes
neurotechnology
chronic recordings
Author
Christian Böhler
University of Freiburg
Maria Vomero
University of Freiburg
Marisol Soula
NYU Langone Health
Mihály Vöröslakos
NYU Langone Health
Maria Porto Cruz
University of Freiburg
Rickard Liljemalm
University of Freiburg
György Buzsaki
NYU Langone Health
Thomas Stieglitz
University of Freiburg
Maria Asplund
University of Freiburg
Luleå University of Technology
Chalmers, Microtechnology and Nanoscience (MC2), Electronics Material and Systems
Advanced Science
2198-3844 (ISSN) 21983844 (eISSN)
Vol. 10 14 2207576Subject Categories
Other Medical Engineering
Medical Equipment Engineering
Medical Biotechnology
DOI
10.1002/advs.202207576
PubMed
36935361