Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants

Christian Böhler; Maria Vomero; Marisol Soula; Mihály Vöröslakos; Maria Porto Cruz; Rickard Liljemalm; György Buzsaki; Thomas Stieglitz; Maria Asplund

doi:10.1002/advs.202207576

Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants
Artikel i vetenskaplig tidskrift, 2023

Flexible implantable neurointerfaces show great promise in addressing one of the major challenges of implantable neurotechnology, namely the loss of signal connected to unfavorable probe tissue interaction. The authors here show how multilayer polyimide probes allow high-density intracortical recordings to be combined with a reliable long-term stable tissue interface, thereby progressing toward chronic stability of implantable neurotechnology. The probes could record 10–60 single units over 5 months with a consistent peak-to-peak voltage at dimensions that ensure robust handling and insulation longevity. Probes that remain in intimate contact with the signaling tissue over months to years are a game changer for neuroscience and, importantly, open up for broader clinical translation of systems relying on neurotechnology to interface the human brain.

bioelectronics

tissue-device interfaces

conducting polymers

flexible probes

neurotechnology

chronic recordings