Effects on Serum Hormone Concentrations after a Dietary Phytoestrogen Intervention in Patients with Prostate Cancer: A Randomized Controlled Trial
Journal article, 2023

Phytoestrogens have been suggested to have an anti-proliferative role in prostate cancer, potentially by acting through estrogen receptor beta (ERβ) and modulating several hormones. We primarily aimed to investigate the effect of a phytoestrogen intervention on hormone concentrations in blood depending on the ERβ genotype. Patients with low and intermediate-risk prostate cancer, scheduled for radical prostatectomy, were randomized to an intervention group provided with soybeans and flaxseeds (∼200 mg phytoestrogens/d) added to their diet until their surgery, or a control group that was not provided with any food items. Both groups received official dietary recommendations. Blood samples were collected at baseline and endpoint and blood concentrations of different hormones and phytoestrogens were analyzed. The phytoestrogen-rich diet did not affect serum concentrations of testosterone, insulin-like growth factor 1, or sex hormone-binding globulin (SHBG). However, we found a trend of decreased risk of increased serum concentration of estradiol in the intervention group compared to the control group but only in a specific genotype of ERβ (p = 0.058). In conclusion, a high daily intake of phytoestrogen-rich foods has no major effect on hormone concentrations but may lower the concentration of estradiol in patients with prostate cancer with a specific genetic upset of ERβ.

prostate cancer



sex hormone-binding globulin

insulin-like growth factor 1





Rebecca Ahlin

University of Gothenburg

N. Nørskov

Aarhus University

Sanna Nybacka

University of Gothenburg

Rikard Landberg

Chalmers, Life Sciences, Food and Nutrition Science

Viktor Skokic

University of Gothenburg

Karolinska Institutet

Karolinska University Hospital

Johan Stranne

University of Gothenburg

Sahlgrenska University Hospital

Andreas Josefsson

Umeå University

University of Gothenburg

Gunnar Steineck

University of Gothenburg

M. Hedelin

University of Gothenburg

Sahlgrenska University Hospital


2072-6643 (ISSN) 20726643 (eISSN)

Vol. 15 7 1792

Subject Categories

Endocrinology and Diabetes

Urology and Nephrology

Nutrition and Dietetics



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5/9/2023 8