Effects on Serum Hormone Concentrations after a Dietary Phytoestrogen Intervention in Patients with Prostate Cancer: A Randomized Controlled Trial
Artikel i vetenskaplig tidskrift, 2023

Phytoestrogens have been suggested to have an anti-proliferative role in prostate cancer, potentially by acting through estrogen receptor beta (ERβ) and modulating several hormones. We primarily aimed to investigate the effect of a phytoestrogen intervention on hormone concentrations in blood depending on the ERβ genotype. Patients with low and intermediate-risk prostate cancer, scheduled for radical prostatectomy, were randomized to an intervention group provided with soybeans and flaxseeds (∼200 mg phytoestrogens/d) added to their diet until their surgery, or a control group that was not provided with any food items. Both groups received official dietary recommendations. Blood samples were collected at baseline and endpoint and blood concentrations of different hormones and phytoestrogens were analyzed. The phytoestrogen-rich diet did not affect serum concentrations of testosterone, insulin-like growth factor 1, or sex hormone-binding globulin (SHBG). However, we found a trend of decreased risk of increased serum concentration of estradiol in the intervention group compared to the control group but only in a specific genotype of ERβ (p = 0.058). In conclusion, a high daily intake of phytoestrogen-rich foods has no major effect on hormone concentrations but may lower the concentration of estradiol in patients with prostate cancer with a specific genetic upset of ERβ.

prostate cancer



sex hormone-binding globulin

insulin-like growth factor 1





Rebecca Ahlin

Göteborgs universitet

N. Nørskov

Aarhus Universitet

Sanna Nybacka

Göteborgs universitet

Rikard Landberg

Chalmers, Life sciences, Livsmedelsvetenskap

Viktor Skokic

Göteborgs universitet

Karolinska Institutet

Karolinska universitetssjukhuset

Johan Stranne

Göteborgs universitet

Sahlgrenska universitetssjukhuset

Andreas Josefsson

Umeå universitet

Göteborgs universitet

Gunnar Steineck

Göteborgs universitet

M. Hedelin

Göteborgs universitet

Sahlgrenska universitetssjukhuset


2072-6643 (ISSN) 20726643 (eISSN)

Vol. 15 7 1792


Endokrinologi och diabetes

Urologi och njurmedicin




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