Multiscale X-ray imaging and characterisation of pharmaceutical dosage forms
Journal article, 2023

A correlative, multiscale imaging methodology for visualising and quantifying the morphology of solid dosage forms by combining ptychographic X-ray computed nanotomography (PXCT) and scanning small- and wide-angle X-ray scattering (S/WAXS) is presented. The methodology presents a workflow for multiscale analysis, where structures are characterised from the nanometre to millimetre regime. Here, the method is demonstrated by characterising a hot-melt extruded, partly crystalline, solid dispersion of carbamazepine in ethyl cellulose. Characterisation of the morphology and solid-state phase of the drug in solid dosage forms is central as this affects the performance of the final formulation. The 3D morphology was visualised at a resolution of 80 nm over an extended volume through PXCT, revealing an oriented structure of crystalline drug domains aligned in the direction of extrusion. Scanning S/WAXS showed that the nanostructure is similar over the cross section of the extruded filament, with minor radial changes in domain sizes and degree of orientation. The polymorphic forms of carbamazepine were qualified with WAXS, showing a heterogeneous distribution of the metastable forms I and II. This demonstrates the methodology for multiscale structural characterization and imaging to enable a better understanding of the relationships between morphology, performance, and processing conditions of solid dosage forms.

Solid dispersion

Carbamazepine

Ptychographic X-ray computed nanotomography

μXRD

Scanning SAXS/WAXS

Author

Martina Olsson

Chalmers, Physics, Materials Physics

Rydvikha Govender

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry

AstraZeneca AB

Ana Diaz

Paul Scherrer Institut

M. Holler

Paul Scherrer Institut

Andreas Menzel

Paul Scherrer Institut

Susanna Abrahmsén-Alami

AstraZeneca AB

Matthew Sadd

Chalmers, Physics, Materials Physics

Anette Larsson

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry

Aleksandar Matic

Chalmers, Physics, Materials Physics

Marianne Liebi

Paul Scherrer Institut

Swiss Federal Institute of Technology in Lausanne (EPFL)

International Journal of Pharmaceutics

0378-5173 (ISSN) 1873-3476 (eISSN)

Vol. 642 123200

Avbildning av nanostrukturen hos farmaceutiska formuleringar med avancerade röntgentekniker

VINNOVA (2019-02568), 2019-06-19 -- 2020-06-18.

Subject Categories

Pharmaceutical Chemistry

Pharmaceutical Sciences

Areas of Advance

Health Engineering

DOI

10.1016/j.ijpharm.2023.123200

PubMed

37414373

More information

Latest update

7/25/2023