Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
Journal article, 2023
Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge of NAD+ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD+ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with cold-stimulated BAT activation have decreased levels of metabolites from the de novo NAD+ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlate negatively. Furthermore, the expression of genes involved in NAD+ biosynthesis in BAT is related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD+ metabolism is activated upon cold in humans and is probably regulated in a coordinated fashion by several tissues.
BAT
nicotinamide
CP: Metabolism
tryptophan
human brown adipose tissue
cold exposure
NAD +
Author
Mueez U-Din
University of Turku
Vanessa D. de Mello
University of Eastern Finland
Marjo Tuomainen
University of Eastern Finland
Juho Raiko
University of Turku
Tarja Niemi
University of Turku
Tobias Fromme
Technical University of Munich
Anton Klåvus
University of Eastern Finland
Nadine Gautier
University of Côte d'Azur
Kimmo Haimilahti
University of Helsinki
Marko Lehtonen
University of Eastern Finland
Karsten Kristiansen
University of Copenhagen
John W. Newman
University of California
USDA
K. H. Pietilainen
Helsinki University Central Hospital
University of Helsinki
Jussi Pihlajamäki
Kuopio University Hospital
University of Eastern Finland
Ez Zoubir Amri
University of Côte d'Azur
Martin Klingenspor
Technical University of Munich
Pirjo Nuutila
University of Turku
Eija Pirinen
University of Helsinki
University of Oulu
Kati Hanhineva
University of Eastern Finland
Chalmers, Life Sciences, Food and Nutrition Science
University of Turku
Kirsi A. Virtanen
University of Turku
Kuopio University Hospital
University of Eastern Finland
Cell Reports
22111247 (eISSN)
Vol. 42 9 113131Subject Categories
Biochemistry and Molecular Biology
Cell and Molecular Biology
DOI
10.1016/j.celrep.2023.113131
PubMed
37708023