Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
Artikel i vetenskaplig tidskrift, 2023
Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge of NAD+ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD+ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with cold-stimulated BAT activation have decreased levels of metabolites from the de novo NAD+ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlate negatively. Furthermore, the expression of genes involved in NAD+ biosynthesis in BAT is related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD+ metabolism is activated upon cold in humans and is probably regulated in a coordinated fashion by several tissues.
BAT
nicotinamide
CP: Metabolism
tryptophan
human brown adipose tissue
cold exposure
NAD +
Författare
Mueez U-Din
Turun Yliopisto
Vanessa D. de Mello
Itä-Suomen Yliopisto
Marjo Tuomainen
Itä-Suomen Yliopisto
Juho Raiko
Turun Yliopisto
Tarja Niemi
Turun Yliopisto
Tobias Fromme
Technische Universität München
Anton Klåvus
Itä-Suomen Yliopisto
Nadine Gautier
Université Côte d'Azur
Kimmo Haimilahti
Helsingin Yliopisto
Marko Lehtonen
Itä-Suomen Yliopisto
Karsten Kristiansen
Köpenhamns universitet
John W. Newman
University of California
USDA
K. H. Pietilainen
Helsinki University Central Hospital
Helsingin Yliopisto
Jussi Pihlajamäki
Kuopio University Hospital
Itä-Suomen Yliopisto
Ez Zoubir Amri
Université Côte d'Azur
Martin Klingenspor
Technische Universität München
Pirjo Nuutila
Turun Yliopisto
Eija Pirinen
Helsingin Yliopisto
Oulun Yliopisto
Kati Hanhineva
Itä-Suomen Yliopisto
Chalmers, Life sciences, Livsmedelsvetenskap
Turun Yliopisto
Kirsi A. Virtanen
Turun Yliopisto
Kuopio University Hospital
Itä-Suomen Yliopisto
Cell Reports
22111247 (eISSN)
Vol. 42 9 113131Ämneskategorier
Biokemi och molekylärbiologi
Cell- och molekylärbiologi
DOI
10.1016/j.celrep.2023.113131
PubMed
37708023