Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study
Journal article, 2024
Biomarkers associated with dietary fibre intake, as complements to traditional dietary assessment tools, may improve the understanding of its role in human health. Our aim was to discover metabolite biomarkers related to dietary fibre intake and investigate their association with cardiometabolic risk factors. We used data and samples from the Danish Diet Cancer and Health Next Generation (DCH-NG) MAX-study, a one-year observational study with evaluations at baseline, six and 12 months (n = 624, 55% female, mean age: 43 years, 1353 observations). Direct associations between fibre intake and plasma concentrations of 2,6-dihydroxybenzoic acid (2,6-DHBA) and indolepropionic acid were observed at the three time-points. Both metabolites showed an intraclass-correlation coefficient (ICC) > 0.50 and were associated with the self-reported intake of wholegrain cereals, and of fruits and vegetables, respectively. Other metabolites associated with dietary fibre intake were linolenoyl carnitine, 2-aminophenol, 3,4-DHBA, and proline betaine. Based on the metabolites associated with dietary fibre intake we calculated predicted values of fibre intake using a multivariate, machine-learning algorithm. Metabolomics-based predicted fibre, but not self-reported fibre values, showed negative associations with cardiometabolic risk factors (i.e. high sensitivity C-reactive protein, systolic and diastolic blood pressure, all FDR-adjusted p-values <0.05). Furthermore, different correlations with gut microbiota composition were observed. In conclusion, 2,6-DHBA and indolepropionic acid in plasma may better link dietary fibre intake with its metabolic effects than self-reported values. These metabolites may represent a novel class of biomarkers reflecting both dietary exposure and host and/or gut microbiota characteristics providing a read-out that is differentially related to cardiometabolic risk.
Author
Andrea Unión-Caballero
CIBER - Centro de Investigación Biomédica en Red
University of Barcelona
Tomás Meroño
University of Barcelona
CIBER - Centro de Investigación Biomédica en Red
Raul Zamora-Ros
Institut d'Investigació Biomedica de Bellvitge
Agneta Rostgaard-Hansen
Danish Cancer Research Society Center
Antonio Miñarro
CIBER - Centro de Investigación Biomédica en Red
University of Barcelona
Alex Sánchez-Pla
University of Barcelona
CIBER - Centro de Investigación Biomédica en Red
Núria Estanyol-Torres
University of Barcelona
Miriam Martínez-Huelamo
University of Barcelona
CIBER - Centro de Investigación Biomédica en Red
Marta Cubedo
CIBER - Centro de Investigación Biomédica en Red
University of Barcelona
Raúl González-Domínguez
University of Barcelona
Anne Tjønneland
Danish Cancer Research Society Center
Gabrielle Riccardi
University of Naples Federico II
Rikard Landberg
Chalmers, Life Sciences, Food and Nutrition Science
Jytte Halkjær
Danish Cancer Research Society Center
Cristina Andres-Lacueva
University of Barcelona
CIBER - Centro de Investigación Biomédica en Red
Food and Function
2042-6496 (ISSN) 2042-650X (eISSN)
Vol. 15 3 1643-1654Optimal kost utifrån metabotyp för hälsa och vällevnad
Formas (2016-00314), 2016-01-01 -- 2021-12-31.
Discovery and valdiation of novel biomarkers of gut microbiota, diet and their interactions associated with type 2 diabetes risk
Swedish Research Council (VR) (2019-01264), 2020-01-01 -- 2022-12-31.
Subject Categories (SSIF 2011)
Cancer and Oncology
Nutrition and Dietetics
DOI
10.1039/d3fo04763f
PubMed
38247399