Metabolome biomarkers linking dietary fibre intake with cardiometabolic effects: results from the Danish Diet, Cancer and Health-Next Generations MAX study
Artikel i vetenskaplig tidskrift, 2024

Biomarkers associated with dietary fibre intake, as complements to traditional dietary assessment tools, may improve the understanding of its role in human health. Our aim was to discover metabolite biomarkers related to dietary fibre intake and investigate their association with cardiometabolic risk factors. We used data and samples from the Danish Diet Cancer and Health Next Generation (DCH-NG) MAX-study, a one-year observational study with evaluations at baseline, six and 12 months (n = 624, 55% female, mean age: 43 years, 1353 observations). Direct associations between fibre intake and plasma concentrations of 2,6-dihydroxybenzoic acid (2,6-DHBA) and indolepropionic acid were observed at the three time-points. Both metabolites showed an intraclass-correlation coefficient (ICC) > 0.50 and were associated with the self-reported intake of wholegrain cereals, and of fruits and vegetables, respectively. Other metabolites associated with dietary fibre intake were linolenoyl carnitine, 2-aminophenol, 3,4-DHBA, and proline betaine. Based on the metabolites associated with dietary fibre intake we calculated predicted values of fibre intake using a multivariate, machine-learning algorithm. Metabolomics-based predicted fibre, but not self-reported fibre values, showed negative associations with cardiometabolic risk factors (i.e. high sensitivity C-reactive protein, systolic and diastolic blood pressure, all FDR-adjusted p-values <0.05). Furthermore, different correlations with gut microbiota composition were observed. In conclusion, 2,6-DHBA and indolepropionic acid in plasma may better link dietary fibre intake with its metabolic effects than self-reported values. These metabolites may represent a novel class of biomarkers reflecting both dietary exposure and host and/or gut microbiota characteristics providing a read-out that is differentially related to cardiometabolic risk.

Författare

Andrea Unión-Caballero

Universitat de Barcelona

Centro de Investigación Biomédica en Red Sobre Fragilidad y Envejecimiento Saludable

Tomás Meroño

Universitat de Barcelona

Centro de Investigación Biomédica en Red Sobre Fragilidad y Envejecimiento Saludable

Raul Zamora-Ros

Institut d'Investigació Biomedica de Bellvitge

Agneta Rostgaard-Hansen

Danish Cancer Research Society Center

Antonio Miñarro

Centro de Investigación Biomédica en Red Sobre Fragilidad y Envejecimiento Saludable

Universitat de Barcelona

Alex Sánchez-Pla

Universitat de Barcelona

Centro de Investigación Biomédica en Red Sobre Fragilidad y Envejecimiento Saludable

Núria Estanyol-Torres

Universitat de Barcelona

Miriam Martínez-Huelamo

Centro de Investigación Biomédica en Red Sobre Fragilidad y Envejecimiento Saludable

Universitat de Barcelona

Marta Cubedo

Centro de Investigación Biomédica en Red Sobre Fragilidad y Envejecimiento Saludable

Universitat de Barcelona

Raúl González-Domínguez

Universitat de Barcelona

Anne Tjønneland

Danish Cancer Research Society Center

Gabrielle Riccardi

Universita degli Studi di Napoli Federico II

Rikard Landberg

Chalmers, Life sciences, Livsmedelsvetenskap

Jytte Halkjær

Danish Cancer Research Society Center

Cristina Andres-Lacueva

Centro de Investigación Biomédica en Red Sobre Fragilidad y Envejecimiento Saludable

Universitat de Barcelona

Food and Function

2042-6496 (ISSN) 2042-650X (eISSN)

Vol. 15 3 1643-1654

Optimal kost utifrån metabotyp för hälsa och vällevnad

Formas (2016-00314), 2016-01-01 -- 2021-12-31.

Nya blodbaserade biomarkörer för spegling av mikrobiota, kost och deras interaktion associerad med typ 2 diabetes risk

Vetenskapsrådet (VR) (2019-01264), 2020-01-01 -- 2022-12-31.

Ämneskategorier

Cancer och onkologi

Näringslära

DOI

10.1039/d3fo04763f

PubMed

38247399

Mer information

Senast uppdaterat

2024-03-07