Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
Journal article, 2024

We investigated data-driven and hypothesis-driven dietary patterns and their association to plasma metabolite profiles and subsequent colorectal cancer (CRC) risk in 680 CRC cases and individually matched controls. Dietary patterns were identified from combined exploratory/confirmatory factor analysis. We assessed association to LC–MS metabolic profiles by random forest regression and to CRC risk by multivariable conditional logistic regression. Principal component analysis was used on metabolite features selected to reflect dietary exposures. Component scores were associated to CRC risk and dietary exposures using partial Spearman correlation. We identified 12 data-driven dietary patterns, of which a breakfast food pattern showed an inverse association with CRC risk (OR per standard deviation increase 0.89, 95% CI 0.80–1.00, p = 0.04). This pattern was also inversely associated with risk of distal colon cancer (0.75, 0.61–0.96, p = 0.01) and was more pronounced in women (0.69, 0.49–0.96, p = 0.03). Associations between meat, fast-food, fruit soup/rice patterns and CRC risk were modified by tumor location in women. Alcohol as well as fruit and vegetables associated with metabolite profiles (Q2 0.22 and 0.26, respectively). One metabolite reflecting alcohol intake associated with increased CRC risk, whereas three metabolites reflecting fiber, wholegrain, and fruit and vegetables associated with decreased CRC risk.


Stina Bodén

Umeå University

Rui Zheng

Uppsala University

Anton Ribbenstedt

Chalmers, Life Sciences, Systems and Synthetic Biology

Rikard Landberg

Chalmers, Life Sciences, Food and Nutrition Science

Sophia Harlid

Umeå University

Linda Vidman

Umeå University

Marc Gunter

International Agency for Research on Cancer (IARC)

Imperial College London

Anna Winkvist

Umeå University

University of Gothenburg

Ingegerd Johansson

Umeå University

B. van Guelpen

Umeå University

Carl Brunius

Chalmers, Life Sciences, Food and Nutrition Science

Scientific Reports

2045-2322 (ISSN) 20452322 (eISSN)

Vol. 14 1 2244

Subject Categories

Public Health, Global Health, Social Medicine and Epidemiology

Cancer and Oncology

Nutrition and Dietetics





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2/9/2024 9