Recent advances in precision nutrition and cardiometabolic diseases
Review article, 2025
A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their related pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: a) developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; b) incorporating more diverse populations and a broader range of dietary patterns; and c) conducting more translational research to bridge the gap between precision nutrition studies and clinical applications.
Type 2 diabetes
Ischemic heart disease
Nutritional epidemiology
Mediterranean diet
Cardiovascular disease
Metabolomics
Precision nutrition
Author
Miguel A. Martínez-González
University of Navarra
Instituto de Investigación Sanitaria de Navarra (IdiSNA)
Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
Harvard University
Francisco J. Planes
Tecnun University of Navarra
Miguel Ruiz-Canela
Instituto de Investigación Sanitaria de Navarra (IdiSNA)
University of Navarra
Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
Estefania Toledo
Instituto de Investigación Sanitaria de Navarra (IdiSNA)
Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
University of Navarra
Ramon Estruch
University of Barcelona
Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
Jordi Salas-Salvadó
Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
Rovira i Virgili University
Rafael Valdés-Más
Weizmann Institute of Science
Pedro Mena
University of Parma
Olga Castañer
CIBER - Centro de Investigación Biomédica en Red
Montserrat Fitó
Hospital del Mar Medical Research Institute
Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
Clary B. Clish
Broad Institute
Rikard Landberg
Chalmers, Life Sciences, Food and Nutrition Science
Clemens Wittenbecher
Chalmers, Life Sciences, Food and Nutrition Science
Liming Liang
Harvard University
Marta Guasch-Ferré
University of Copenhagen
Harvard University
Rosa M. Lamuela-Raventós
University of Barcelona
Dong D. Wang
Harvard University
Brigham and Women's Hospital
Broad Institute
Nita Forouhi
University of Cambridge
Cristina Razquin
Instituto de Investigación Sanitaria de Navarra (IdiSNA)
Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
University of Navarra
Frank B. Hu
Harvard University
Brigham and Women's Hospital
Revista Espanola de Cardiologia
0300-8932 (ISSN) 15792242 (eISSN)
Vol. 78 3 263-271Subject Categories (SSIF 2011)
Endocrinology and Diabetes
Cardiac and Cardiovascular Systems
Nutrition and Dietetics
DOI
10.1016/j.recesp.2024.09.005
PubMed
39357800