Recent advances in precision nutrition and cardiometabolic diseases
Reviewartikel, 2025

A growing body of research on nutrition omics has led to recent advances in cardiovascular disease epidemiology and prevention. Within the PREDIMED trial, significant associations between diet-related metabolites and cardiovascular disease were identified, which were subsequently replicated in independent cohorts. Some notable metabolites identified include plasma levels of ceramides, acyl-carnitines, branched-chain amino acids, tryptophan, urea cycle pathways, and the lipidome. These metabolites and their related pathways have been associated with incidence of both cardiovascular disease and type 2 diabetes. Future directions in precision nutrition research include: a) developing more robust multimetabolomic scores to predict long-term risk of cardiovascular disease and mortality; b) incorporating more diverse populations and a broader range of dietary patterns; and c) conducting more translational research to bridge the gap between precision nutrition studies and clinical applications.

Ischemic heart disease

Metabolomics

Type 2 diabetes

Cardiovascular disease

Mediterranean diet

Nutritional epidemiology

Precision nutrition

Författare

Miguel A. Martínez-González

Universidad de Navarra

Harvard School of Public Health

Instituto de Investigación Sanitaria de Navarra (IdiSNA)

Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición

Francisco J. Planes

Tecnun University of Navarra

Miguel Ruiz-Canela

Universidad de Navarra

Instituto de Investigación Sanitaria de Navarra (IdiSNA)

Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición

Estefania Toledo

Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición

Universidad de Navarra

Instituto de Investigación Sanitaria de Navarra (IdiSNA)

Ramon Estruch

Universitat de Barcelona

Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición

Jordi Salas-Salvadó

Universitat Rovira i Virgili

Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición

Rafael Valdés-Más

Weizmann Institute of Science

Pedro Mena

Universita degli Studi di Parma

Olga Castañer

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública

Montserrat Fitó

Hospital del Mar Medical Research Institute

Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición

Clary B. Clish

Broad Institute

Rikard Landberg

Chalmers, Life sciences, Livsmedelsvetenskap

Clemens Wittenbecher

Chalmers, Life sciences, Livsmedelsvetenskap

Liming Liang

Harvard School of Public Health

Marta Guasch-Ferré

Köpenhamns universitet

Harvard School of Public Health

Rosa M. Lamuela-Raventós

Universitat de Barcelona

Dong D. Wang

Broad Institute

Brigham and Women's Hospital

Harvard School of Public Health

Nita Forouhi

University of Cambridge

Cristina Razquin

Universidad de Navarra

Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición

Instituto de Investigación Sanitaria de Navarra (IdiSNA)

Frank B. Hu

Brigham and Women's Hospital

Harvard School of Public Health

Revista Espanola de Cardiologia

0300-8932 (ISSN) 15792242 (eISSN)

Vol. 78 3 263-271

Ämneskategorier (SSIF 2011)

Endokrinologi och diabetes

Kardiologi

Näringslära

DOI

10.1016/j.recesp.2024.09.005

PubMed

39357800

Mer information

Senast uppdaterat

2025-03-08