Programming of synthetic regulatory DNA for cell-type targeting in humans
Other text in scientific journal, 2025
In a recent study in Nature, Gosai et al.1 introduce a framework to engineer and validate synthetic DNA regulatory elements showing cell-type-specific activity in human cell lines, closing the distance to the machine-driven design of functional regulatory sequences with therapeutic applications in humans.
Author
Leandro N. Ventimiglia
King's College London
Aleksej Zelezniak
Vilnius University
Chalmers, Life Sciences, Systems and Synthetic Biology
King's College London
Molecular Cell
1097-2765 (ISSN) 1097-4164 (eISSN)
Vol. 85 2 205-207Using AI to unravel "DNA grammar" for synthetic biology applications
Swedish Research Council (VR) (2019-05356), 2020-01-01 -- 2024-12-31.
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Subject Categories (SSIF 2025)
Basic Medicine
DOI
10.1016/j.molcel.2024.12.019