Programming of synthetic regulatory DNA for cell-type targeting in humans
Other text in scientific journal, 2025
In a recent study in Nature, Gosai et al.1 introduce a framework to engineer and validate synthetic DNA regulatory elements showing cell-type-specific activity in human cell lines, closing the distance to the machine-driven design of functional regulatory sequences with therapeutic applications in humans.
Author
Leandro N. Ventimiglia
Faculty of Life Sciences & Medicine
Aleksej Zelezniak
Vilnius University
Chalmers, Life Sciences, Systems and Synthetic Biology
Faculty of Life Sciences & Medicine
Molecular Cell
1097-2765 (ISSN) 1097-4164 (eISSN)
Vol. 85 2 205-207Subject Categories (SSIF 2025)
Basic Medicine
DOI
10.1016/j.molcel.2024.12.019