Programming of synthetic regulatory DNA for cell-type targeting in humans
Övrig text i vetenskaplig tidskrift, 2025
In a recent study in Nature, Gosai et al.1 introduce a framework to engineer and validate synthetic DNA regulatory elements showing cell-type-specific activity in human cell lines, closing the distance to the machine-driven design of functional regulatory sequences with therapeutic applications in humans.
Författare
Leandro N. Ventimiglia
Faculty of Life Sciences & Medicine
Aleksej Zelezniak
Vilniaus universitetas
Chalmers, Life sciences, Systembiologi
Faculty of Life Sciences & Medicine
Molecular Cell
1097-2765 (ISSN) 1097-4164 (eISSN)
Vol. 85 2 205-207Ämneskategorier (SSIF 2025)
Medicinska och farmaceutiska grundvetenskaper
DOI
10.1016/j.molcel.2024.12.019