Precision nutrition for cardiometabolic diseases
Review article, 2025
Precision nutrition is a vibrant and rapidly evolving field of scientific research and innovation with the potential to deliver health, societal and economic benefits by improving healthcare delivery and policies. Advances in deep phenotyping technologies, digital tools and artificial intelligence have made possible early proof-of-concept research that expands the understanding of within- and between-person variability in responses to diet. These studies illustrate the promise of precision nutrition to complement the traditional ‘one size fits all’ dietary guidelines, which, while considering broad life-stage and disease-specific nutritional requirements, often lack the granularity to account fully for individual variations in nutritional needs and dietary responses. Despite these developments, however, considerable challenges remain before precision nutrition can be implemented on a broader scale. This Review examines the current state of precision nutrition research, with a focus on its application to reducing the incidence and burden of cardiometabolic diseases. We critically examine the evidence base, explore the potential benefits and discuss the challenges and opportunities ahead.
Author
Marta Guasch-Ferré
Harvard University
Novo Nordisk Foundation
University of Copenhagen
Clemens Wittenbecher
Chalmers, Life Sciences, Food and Nutrition Science
Marie Palmnäs
Chalmers, Life Sciences, Food and Nutrition Science
Orly Ben-Yacov
Weizmann Institute of Science
Ellen E. Blaak
Maastricht University
Christina C. Dahm
Aarhus University
Tove Fall
Uppsala University
Berit L. Heitmann
Frederiksberg Hospital
The University of Sydney
University of Copenhagen
Tine Rask Licht
Technical University of Denmark (DTU)
M. Lof
Karolinska Institutet
Linköping University
Ruth Loos
Novo Nordisk Foundation
Chirag J. Patel
Harvard University
Carmelo Quarta
University of Bordeaux
Leanne M. Redman
Pennington Biomedical Research Center
Eran Segal
Weizmann Institute of Science
Nicola Segata
University of Trento
European Institute of Oncology
Michael P. Snyder
Stanford University
Qi Sun
Brigham and Women's Hospital
Harvard University
Deirdre K. Tobias
Brigham and Women's Hospital
Harvard University
Frank B. Hu
Harvard University
Brigham and Women's Hospital
Paul W. Franks
University of Oxford
Harvard University
Lund University
Rikard Landberg
Chalmers, Life Sciences, Food and Nutrition Science
Jennifer L. Sargent
Department of Metabolism
BabelFisk
Jordi Merino
Massachusetts General Hospital
Novo Nordisk Foundation
Broad Institute
Nature Medicine
1078-8956 (ISSN) 1546170x (eISSN)
Vol. 31 5 1444-1453The metabolomics imprint of controlled modification of carbohydrate quality elucidates long-term impact on cardiometabolic disease risk and facilitates precision prevention approaches
Swedish Research Council (VR) (2022-01529), 2023-01-01 -- 2026-12-31.
Subject Categories (SSIF 2025)
Nutrition and Dietetics
DOI
10.1038/s41591-025-03669-9
PubMed
40307513