Non-Destructive Characterization Of Pharmaceutical Tablets Using Terahertz Frequency Domain Spectroscopy
Paper in proceedings, 2019

In this paper, terahertz frequency domain spectroscopy (THz-FDS) in transmission mode is used to study the influence of porosity on effective permittivity in pharmaceutical tablets. Three sets of training tablets with different dielectric constants were generated using microcrystalline cellulose (MCC), Benzophenone and Succinic acid. In each set, various compaction forces have been applied to the powders to produce tablets with different porosity. The results show that the extracted effective permittivity is sensitive to the change of porosity in tablets. Moreover, the results confirm that THz-FDS is able to differentiate between tablets with different dielectric constant and a linear correlation between effective permittivity and tablet density is observed. Therefore, THz-FDS technique is shown to be a promising technique for quality inspection of pharmaceutical tablets. © 2019 IEEE.

Tablets

Porosity

Effective permittivity

THz frequency domain spectroscopy

transmission mode technique

Author

Anis Moradikouchi

Chalmers, Microtechnology and Nanoscience (MC2), Terahertz and Millimetre Wave Laboratory

Martin Lindsjö

AstraZeneca R&D

Jan Stake

Chalmers, Microtechnology and Nanoscience (MC2), Terahertz and Millimetre Wave Laboratory

Staffan Folestad

AstraZeneca R&D

Helena Rodilla

Chalmers, Microtechnology and Nanoscience (MC2), Terahertz and Millimetre Wave Laboratory

International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz

21622027 (ISSN) 21622035 (eISSN)

Vol. 2019-September 8874004

44th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
Paris, France,

Terahertsteknik för tillverkning av moderna läkemedel

Swedish Foundation for Strategic Research (SSF), 2017-12-01 -- 2023-12-31.

Areas of Advance

Information and Communication Technology

Materials Science

Infrastructure

Kollberg Laboratory

Subject Categories

Pharmaceutical Sciences

Electrical Engineering, Electronic Engineering, Information Engineering

DOI

10.1109/IRMMW-THz.2019.8874004

More information

Latest update

3/31/2021