Systems biology of yeast: enabling technology for development of cell factories for production of advanced biofuels
Review article, 2012

Transportation fuels will gradually shift from oil based fuels towards alternative fuel resources like biofuels. Current bioethanol and biodiesel can, however, not cover the increasing demand for biofuels and there is therefore a need for advanced biofuels with superior fuel properties. Novel cell factories will provide a production platform for advanced biofuels. However, deep cellular understanding is required for improvement of current biofuel cell factories. Fast screening and analysis (-omics) methods and metabolome-wide mathematical models are promising techniques. An integrated systems approach of these techniques drives diversity and quantity of several new biofuel compounds. This review will cover the recent technological developments that support improvement of the advanced biofuels 1-butanol, biodiesels and jetfuels.

butanol production

flux

high-throughput

saccharomyces-cerevisiae

expression

metabolism

analysis

escherichia-coli

mass-spectrometry

quantitative metabolomics

acetobutylicum

Author

Bouke Wim de Jong

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Verena Siewers

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Jens B Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Current Opinion in Biotechnology

0958-1669 (ISSN)

Vol. 23 4 624-630

Subject Categories

Biological Sciences

Areas of Advance

Life Science Engineering (2010-2018)

DOI

10.1016/j.copbio.2011.11.021

More information

Latest update

7/20/2021