Reversible Energy-Transfer Switching on a DNA Scaffold
Journal article, 2015

We show that FRET between Pacific Blue (PB) and Alexa488 (A488) covalently attached to a DNA scaffold can be reversibly controlled by photochromic switching of a spiropyran derivative. With the spiropyran in the closed spiro isomeric form, FRET occurs freely between PB and A488. UV-induced isomerization to the open merocyanine form shuts down the FRET process by efficient quenching of the PB excited state. The process is reversed by exposure to visible light, triggering the isomerization to the spiro isomer.

Author

Magnus Bälter

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Martin Hammarson

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Patricia Remón Ruiz

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Shiming Li

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

N. Gale

University of Southampton

T. Brown

University of Oxford

Joakim Andreasson

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Journal of the American Chemical Society

0002-7863 (ISSN) 1520-5126 (eISSN)

Vol. 137 7 2444-2447

Photochromic Systems for Solid State Molecular Electronic Devices and Light-Activated Cancer Drugs (PHOTOCHROMES)

European Commission (FP7), 2008-09-01 -- 2013-08-31.

Subject Categories

Chemical Sciences

DOI

10.1021/ja512416n

More information

Latest update

3/19/2018