Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.
Journal article, 2015

To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia.

multocomnpartmental modeling

apoB

kinetics

stable isotopes

very low density lipoproteins

Author

Martin Adiels

University of Gothenburg

Adil Mardinoglu

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Marja-Riitta Taskinen

Helsinki University Central Hospital

Jan Borén

University of Gothenburg

Frontiers in Physiology

1664-042X (ISSN)

Vol. 6 NOV 342- 342

Subject Categories

Basic Medicine

Clinical Medicine

Bioinformatics (Computational Biology)

Bioinformatics and Systems Biology

DOI

10.3389/fphys.2015.00342

PubMed

26635628

More information

Created

10/8/2017