Estimation of body fluids with bioimpedance spectroscopy: state of the art methods and proposal of novel methods
Journal article, 2015

Determination of body fluids is a useful common practice in determination of disease mechanisms and treatments. Bioimpedance spectroscopy (BIS) methods are non-invasive, inexpensive and rapid alternatives to reference methods such as tracer dilution. However, they are indirect and their robustness and validity are unclear. In this article, state of the art methods are reviewed, their drawbacks identified and new methods are proposed. All methods were tested on a clinical database of patients receiving growth hormone replacement therapy. Results indicated that most BIS methods are similarly accurate (e.g. < 0.5 +/- 3.0% mean percentage difference for total body water) for estimation of body fluids. A new model for calculation is proposed that performs equally well for all fluid compartments (total body water, extra-and intracellular water). It is suggested that the main source of error in extracellular water estimation is due to anisotropy, in total body water estimation to the uncertainty associated with intracellular resistivity and in determination of intracellular water a combination of both.

body fluids estimation


body composition


Ruben Buendia

Chalmers, Signals and Systems, Signal Processing and Biomedical Engineering

Fernando Seoane Martinez

Royal Institute of Technology (KTH)

University of Borås

Kaj Lindecrantz

University of Borås

Karolinska Institutet

Royal Institute of Technology (KTH)

Ingvar Bosaeus

University of Gothenburg

R. Gil-Pita

University of Alcalá

Gudmundur Johannsson

Sahlgrenska University Hospital

Lars Ellegård

Sahlgrenska University Hospital

L. C. Ward

University of Queensland

Physiological Measurement

0967-3334 (ISSN) 13616579 (eISSN)

Vol. 36 10 93-2187

Subject Categories

Clinical Medicine

Biomedical Laboratory Science/Technology



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