Biobased organic acids production by metabolically engineered microorganisms
Journal article, 2016

Bio-based production of organic acids via microbial fermentation has been traditionally used in food industry. With the recent desire to develop more sustainable bioprocesses for production of fuels, chemicals and materials, the market for microbial production of organic acids has been further expanded as organic acids constitute a key group among top building block chemicals that can be produced from renewable resources. Here we review the current status for production of citric acid and lactic acid, and we highlight the use of modern metabolic engineering technologies to develop high performance microbes for production of succinic acid and 3-hydroxypropionic acid. Also, the key limitations and challenges in microbial organic acids production are discussed.

Author

Yun Chen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Current Opinion in Biotechnology

0958-1669 (ISSN)

Vol. 37 165-172

Areas of Advance

Energy

Life Science Engineering

Subject Categories

Other Industrial Biotechnology

DOI

10.1016/j.copbio.2015.11.004

PubMed

26748037

More information

Created

10/7/2017