A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults.
Journal article, 2018

Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.


Henrik Munch Roager

Nadja B. Søndertoft

Hansen LBS

Technical University of Denmark (DTU)

R. J. Gobel

M. Kristensen

Mireia Vallès-Colomer

Sara Vieira-Silva

Mads Vendelbo Lind

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Rasmus B. Mærkedahl

Sabine Ibrügger

Martin I. Bahl

Jesper Havelund

ML Madsen

University of Copenhagen

Inge Tetens

Gwen Falony

Trine Nielsen

Kristine H. Allin

Henrik L. Frandsen

Bolette Hartmann

Jan Holst

Morten H. Sparholt

Jesper Holck

Andreas Blennow

H Moll

A Meyer

Technical University of Denmark (DTU)

Camilla Hoppe

Jørgen H. Poulsen

Vera Carvalho

Domenico Sagnelli

Marlene D. Dalgaard

Anna Christensen

Magnus Christian Lydolph

Alastair Ross

Chalmers, Biology and Biological Engineering, Food and Nutrition Science

Silas G. Villas-Boas

Susanne Brix

T. Sicheritz-Pontén

Karsten Buschard

Allan Linneberg

Jüri J. Rumessen

Chris Ekstrom

Christian Ritz

Karsten Kristiansen

H. H. Nielsen

Henrik Vestergaard

Nils J. Færgeman

Jeroen Raes

Hanne Frøkiær

T. Hansen

Lotte Lauritzen

Rajiv Gupta

Tine Rask Licht

Oluf Pedersen

Nature Communications

2041-1723 (ISSN)

Vol. 13 9 4630


Chalmers Infrastructure for Mass spectrometry

Subject Categories

Food Science

Clinical Science

Nutrition and Dietetics


Basic sciences

Areas of Advance

Life Science Engineering (2010-2018)



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