Tackling Cancer with Yeast-Based Technologies
Review article, 2019
The ability to precisely engineer yeast, coupled with its genetic and metabolic similarity to tumor cells, has enabled researchers to use this organism in cancer research. Here we review advances that leveraged yeast as a model organism for studying cancer biology, including the investigation of tumorigenic mechanisms, development of advanced technologies for drug discovery, production of anticancer drugs on an industrial scale, and delivering the next generation of immunotherapies.
SGA
immunotherapy
cancer vaccines
CRISPR
humanized antibody
metabolic engineering
Author
Raphael Ferreira
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Angelo Limeta
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Jens B Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Technical University of Denmark (DTU)
Trends in Biotechnology
0167-7799 (ISSN) 18793096 (eISSN)
Vol. 37 6 592-603Subject Categories
Medical Biotechnology
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Cancer and Oncology
DOI
10.1016/j.tibtech.2018.11.013