Genome-Scale Metabolic Modeling from Yeast to Human Cell Models of Complex Diseases: Latest Advances and Challenges
Journal article, 2019

Genome-scale metabolic models (GEMs) are mathematical models that enable systematic analysis of metabolism. This modeling concept has been applied to study the metabolism of many organisms including the eukaryal model organism, the yeast Saccharomyces cerevisiae, that also serves as an important cell factory for production of fuels and chemicals. With the application of yeast GEMs, our knowledge of metabolism is increasing. Therefore, GEMs have also been used for modeling human cells to study metabolic diseases. Here we introduce the concept of GEMs and provide a protocol for reconstructing GEMs. Besides, we show the historic development of yeast GEMs and their applications. Also, we review human GEMs as well as their uses in the studies of complex diseases.

Metabolic engineering

Drug target

Genome-scale metabolic models

Human cells

Saccharomyces cerevisiae

Yeast

Biomarker

Systems biology

Author

Yu Chen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Gang Li

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Novo Nordisk Foundation Center for Biosustainability

Jens B Nielsen

Technical University of Denmark (DTU)

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Methods in molecular biology (Clifton, N.J.)

19406029 (eISSN)

Vol. 2049 329-345

Subject Categories

Medical Biotechnology

Bioinformatics (Computational Biology)

Software Engineering

DOI

10.1007/978-1-4939-9736-7_19

PubMed

31602620

More information

Latest update

11/13/2019