Glycan processing in gut microbiomes
Review article, 2022

Microbiomes and their enzymes process many of the nutrients accessible in the gastrointestinal tract of bilaterians and play an essential role in host health and nutrition. In this review, we describe recent insights into nutrient processing in microbiomes across three exemplary yet contrasting gastrointestinal ecosystems (humans, ruminants and insects), with focus on bacterial mechanisms for the utilization of common and atypical dietary glycans as well as host-derived mucus glycans. In parallel, we discuss findings from multi-omic studies that have provided new perspectives on understanding glycan-dependent interactions and the complex food-webs of microbial populations in their natural habitat. Using key examples, we emphasize how increasing understanding of glycan processing by gut microbiomes can provide critical insights to assist ‘microbiome reprogramming’, a growing field that seeks to leverage diet to improve animal growth and host health.

Author

Sabina Leanti La Rosa

Norwegian University of Life Sciences

Matthew Ostrowski

University of Michigan

Arturo Vera-Ponce de León

Norwegian University of Life Sciences

Lauren S McKee

Royal Institute of Technology (KTH)

Johan Larsbrink

Chalmers, Biology and Biological Engineering, Industrial Biotechnology

Vincent G.H. Eijsink

Norwegian University of Life Sciences

Elisabeth Lowe

Newcastle University

Eric Martens

University of Michigan

Phillip B. Pope

Norwegian University of Life Sciences

Current Opinion in Microbiology

1369-5274 (ISSN) 18790364 (eISSN)

Vol. 67 102143

Development of a consolidated bioprocess for conversion of plant biomass to versatile chemical building blocks

ÅForsk (17-345), 2017-07-01 -- 2018-05-31.

Swedish Research Council (VR) (2016-03931), 2017-01-01 -- 2020-12-31.

Novo Nordisk Foundation (NNF17OC0027648), 2018-01-01 -- 2020-12-31.

Driving Forces

Sustainable development

Roots

Basic sciences

Areas of Advance

Health Engineering

Life Science Engineering (2010-2018)

Subject Categories

Microbiology

Microbiology in the medical area

Bioinformatics and Systems Biology

DOI

10.1016/j.mib.2022.102143

More information

Latest update

5/31/2022