Kinetic recognition of AT-rich DNA by ruthenium complexes
Journal article, 2007
(Figure Presented) Finding AT tracts: High selectivity for long AT sequences can be attained through kinetically controlled DNA threading intercalation by binuclear ruthenium (II) complexes (see picture). The rate of intercalation is strongly correlated to the number of consecutive AT base pairs and is up to 2500-times higher with poly-(dAdT) 2 than with mixed-sequence DNA. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
TRIS(PHENANTHROLINE)RUTHENIUM(II)
STEREOSELECTIVITY
luminescence
SPECIFICITY
LIGANDS
MINOR-GROOVE
DISSOCIATION
SEQUENCE
kinetics
BINDING
DNA recognition
MODE
intercalation
THREADING INTERCALATION
ruthenium
Author
Pär Nordell
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Fredrik Westerlund
Chalmers
Marcus Wilhelmsson
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Bengt Nordén
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Per Lincoln
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 46 13 2203-2206Subject Categories (SSIF 2011)
Physical Chemistry
DOI
10.1002/anie.200604294