Kinetic recognition of AT-rich DNA by ruthenium complexes
Journal article, 2007

(Figure Presented) Finding AT tracts: High selectivity for long AT sequences can be attained through kinetically controlled DNA threading intercalation by binuclear ruthenium (II) complexes (see picture). The rate of intercalation is strongly correlated to the number of consecutive AT base pairs and is up to 2500-times higher with poly-(dAdT) 2 than with mixed-sequence DNA. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

TRIS(PHENANTHROLINE)RUTHENIUM(II)

STEREOSELECTIVITY

luminescence

SPECIFICITY

LIGANDS

MINOR-GROOVE

DISSOCIATION

SEQUENCE

kinetics

BINDING

DNA recognition

MODE

intercalation

THREADING INTERCALATION

ruthenium

Author

Pär Nordell

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Other publications Research

Fredrik Westerlund

Chalmers

Other publications Research

Marcus Wilhelmsson

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Other publications Research

Bengt Nordén

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Other publications Research

Per Lincoln

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Other publications Research

Angewandte Chemie - International Edition

1433-7851 (ISSN) 1521-3773 (eISSN)

Vol. 46 13 2203-2206

Subject Categories

Physical Chemistry

DOI

10.1002/anie.200604294

Publication data connected to DOI

More information

Latest update

9/10/2018

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