Molecular Lipid Films on Microengineering Materials
Journal article, 2019

In this study, we have systematically investigated the formation of molecular phospholipid films on a variety of solid substrates fabricated from typical surface engineering materials and the fluidic properties of the lipid membranes formed on these substrates. The surface materials comprise of borosilicate glass, mica, SiO2, Al (native oxide), Al2O3, TiO2, ITO, SiC, Au, Teflon AF, SU-8, and graphene. We deposited the lipid films from small unilamellar vesicles (SUVs) by means of an open-space microfluidic device, observed the formation and development of the films by laser scanning confocal microscopy, and evaluated the mode and degree of coverage, fluidity, and integrity. In addition to previously established mechanisms of lipid membrane–surface interaction upon bulk addition of SUVs on solid supports, we observed nontrivial lipid adhesion phenomena, including reverse rolling of spreading bilayers, spontaneous nucleation and growth of multilamellar vesicles, and the formation of intact circular patches of double lipid bilayer membranes. Our findings allow for accurate prediction of membrane–surface interactions in microfabricated devices and experimental environments where model membranes are used as functional biomimetic coatings.

Author

Silver Jõemetsa

Chalmers, Physics, Biological Physics

Kiryl Kustanovich

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Severin Schindler

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Tatsiana Lobovkina

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Samuel Lara Avila

Chalmers, Microtechnology and Nanoscience (MC2), Quantum Device Physics

Aldo Jesorka

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Irep Gözen

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Langmuir

07437463 (ISSN) 15205827 (eISSN)

Vol. 35 32 10286-10298

Subject Categories

Physical Chemistry

Materials Chemistry

Water Treatment

Infrastructure

Nanofabrication Laboratory

DOI

10.1021/acs.langmuir.9b01120

PubMed

31369272

More information

Latest update

12/5/2019