Integrating Modelling of Metabolism and Signalling towards an Application in Liver Cancer (ERASysAPP - IMOMESIC)
Forskningsprojekt , 2014 – 2018

Uncontrolled proliferation in cancer results from synergistic adaptations in metabolism and signalling. However, due to the complexity, coupling mechanisms between metabolism and signalling are difficult to assess and it remains to be clarified how they give rise to cooperative enhancement. As a proof of concept, we focus on liver cancer, and propose a combined experimental and modelling approach that exploits both, comprehensive genome-scale models to identify global, cancer-specific alterations as well as a more detailed integrative model that links glycolysis and signalling. We will develop standard operating procedures for combined quantitative studies of metabolism and signal transduction in healthy and cancer cells, elucidate alterations in signalling and gene expression causing glycolytic adaptations and predict cancer-cell selective drug combinations using mathematical modelling of healthy and cancer cells. The proposed approach will act as a model study for systems biology approaches to integrate metabolism and signalling in oncology and will open new avenues for the treatment of liver cancer.

Deltagare

Jens B Nielsen (kontakt)

Professor vid Chalmers, Biologi och bioteknik

Adil Mardinoglu

Forskarassistent vid Chalmers, Biologi och bioteknik, Systembiologi

Avlant Nilsson

Doktorand vid Chalmers, Biologi och bioteknik, Systembiologi

Samarbetspartners

Albert-Ludwigs-Universität Freiburg

Freiburg, Germany

Charité Universitätsmedizin Berlin

Berlin, Germany

Deutsches Krebsforschungszentrum (DKFZ)

Heidelberg, Germany

Griffin Discoveries

Amsterdam, Netherlands

Vrije Universiteit Amsterdam

Amsterdam, Netherlands

Finansiering

Vetenskapsrådet (VR)

Finansierar Chalmers deltagande under 2014–2018

Relaterade styrkeområden och infrastruktur

Hållbar utveckling

Drivkrafter

Publikationer

Mer information

Senast uppdaterat

2017-02-06