Systematic Rebuilding of Actinomycetes for Natural Product Formation (ERASysAPP - SYSTERACT)
Forskningsprojekt , 2015 – 2018

Despite an increasing medical need, the number of new antibiotics approved for human use has been declining over many years. Recently, new molecular genetics and biochemical tools, and in particular Next Generation Sequencing, combined with newly developed bioinformatics approaches, have provided insight into the enormous unexploited genetic pool of environmental microbial biodiversities for the synthesis of potential new bioactive compounds. The main objective of the SYSTERACT project is through an integrated and interdisciplinary approach to develop the model actinomycete Streptomyces coelicolor into a 'Superhost' for the efficient heterologous production of bioactive compounds, enabling a faster discovery of new antibiotics from environmental microbial resources (microbial strains and metagenomes). Central to this approach will be an iterative Systems Biology process, combining microbiology, genetics, biochemistry, and fermentation technology with modelling.

Deltagare

Eduard Kerkhoven (kontakt)

Forskare vid Chalmers, Biologi och bioteknik, Systembiologi

Samarbetspartners

SINTEF

Trondheim, Norway

Universität Rostock

Rostock, Germany

Universität Tübingen

Tübingen, Germany

Universiteit Leiden

Leiden, Netherlands

Finansiering

Västra Götalandsregionen

Finansierar Chalmers deltagande under 2015–2018

Relaterade styrkeområden och infrastruktur

Hållbar utveckling

Drivkrafter

Livsvetenskaper och teknik

Styrkeområden

Mer information

Senast uppdaterat

2015-11-02