Kemisk avbildning för studier av hudupptag
Forskningsprojekt , 2020

In this project we want to develop an animal-free skin permeation analysis approach suitable for testing chemicals such as pharmaceuticals, cosmetics and skin allergens. The method uses multi-modal chemical imaging (MMCI) to trace, quantify and image molecules and elements in donated human skin after a diffusion cell exposure. The method aims to replace or significantly reduce existing in-vivo models and improve on already established in-vitro models. This by offering a more sensitive and flexible analytical approach that can replace and/or complement existing methods in the OECD guidelines for skin adsorption (no 427 and no 428). Although the use of in-vivo testing of cosmetic ingredients with regard to skin sensitizing potency is prohibited since many years, the replacement methods validated by ECVAM does not take skin permeation into account.

Deltagare

Per Malmberg (kontakt)

Senior forskare vid Chalmers, Kemi och kemiteknik, Kemi och biokemi

Samarbetspartners

Sahlgrenska universitetssjukhuset

Gothenburg, Sweden

Finansiering

Forska utan Djurförsök

Finansierar Chalmers deltagande under 2020

Relaterade styrkeområden och infrastruktur

Chalmers infrastruktur för masspektrometri

Infrastruktur

Hälsa och teknik

Styrkeområden

Infrastruktur för kemisk avbildning

Infrastruktur

Mer information

Projektets webbplats

www.permalmberg.se

Senast uppdaterat

2020-02-05