Kinetics of the formation of cancer metastases via induced premetastatic cancer-stem-cell niches
Artikel i vetenskaplig tidskrift, 2009

The author presents a kinetic model describing the formation of new metastases by cancer stem cells in premetastatic stem-cell niches induced by the factors produced by a primary tumor and already formed metastases. The corresponding kinetics is analyzed by employing mean-field kinetic equations and Monte Carlo simulations. In agreement with observations, the model predicts a long latent period with low rate of the metastase growth followed by explosive increase in the number of metastases. The duration of the latent period is found to depend on a multitude of rate constants characterizing various processes.

Författare

Vladimir Zhdanov

Chalmers, Teknisk fysik, Kemisk fysik

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

1539-3755 (ISSN)

Vol. 79 061913-

Ämneskategorier

Atom- och molekylfysik och optik

DOI

10.1103/PhysRevE.79.061913